Yes an opposition 4141 caused some initial problems when I was playing as Man Utd in the first season.
While it depends on which team you are and how your team plays, here is how I’ve mostly solved it. Apologies for the detail, but don’t have a visual tactics board to hand!
I was playing a 4231 - Rashford as an IF on one side (left) Lingard/Greenwood as an IW on the other side (right), with Bruno Fernandes in the middle as an AMC / AP, and Martial up front as a lone AF. But against an opposition 4141 we struggle to make good chances.
There was a consistent problem visible in the highlights, with a number of knock on implications ...
Key point: my AP (Bruno) was marked by the opposition DMC...
... this meant neither of the opposition’s D.C. needed to push up to close Bruno down, so there was less space for my 3 forwards to get in behind.
... this also meant my 2 MC were both man marked by the opposition’s MCs, so they had less opportunities for long shots.
Of course with Martial upfront, there wasn’t many aerial chances from crosses ...
... plus when the opposition are playing contain / defensive, there are fewer chances to go long / get behind their defensive line.
This was mostly solved with a few tactical tweaks.
Move the existing AMC / AP (Bruno) slightly to the right, as an AP centre-right (AMRC)
Moved an MC (Pogba / Fred) forward as an AM in an AMLC position (next to Bruno).
Then move the remaining MC into a central position (e.g. as a BWM).
... and move forward the IF/IW to a fully front 3 - IF left (Rashford), AF central (Martial) and a AF right (Lingard / Greenwood).
... sometimes I’d also change the full backs to be IWBs, to provide more passing options in midfield.
This gives a 4123: with IWBs, a central BWM, a AM and AP playing centrally next to each other in advanced positions, and three up front across the full width.
This meant the front 3 we’re making more penetrative runs inbetween / behind the defence, as they were positioned further forward.
As we had 2xAMC (AM & AP), there were more times where an opposition D.C. had to push up to close them down, leaving space inbetween / behind.
Key point - the central opposition DMC was often ‘slightly’ out of position marking my main AMRC (Bruno), as my guy was positioned slightly to the right, so had slightly more time on his right foot (Bruno’s preferred foot) to play a through ball into my central or right sided forwards (Martial or Greenwood - also into their preferred foot).
This meant my AMRC (Bruno) got the ball with a bit more space from the opposition DMC, so the opposition D.C. pushes up to close him down, allowing space behind that D.C. for my central or right-sided forwards to attack. Was worth a few extra shots a game.
I also noticed that my IWBs had more build up play, occasionally meaning an opposition MCR pushes up to close them down, which means the opposition MCR isn’t marking Pogba / Fred (who is now in the AMLC position), so my AMLC has more free time - to either shoot from distance, or attract the opposition DCR to close them down (giving space for my left sided attacker to attack), or the opposition DMC closes them down, giving more space to my AMRC (Fernandes).
Especially if I made these changes at half time, and ramped up the mentality gradually during the second half, I’d often get more chances & a goal.
Depends who you are and how you play, but maybe worth a try. Did that make sense?