I use 3 at the back with my Juventus save. I have 3 powerful centrebacks with one of them having excellent technical abilities as a BPD. In midfield, it's two wingers with great pace, crossing and movement. A winger with good teamwork is an added bonus as well. Then I use two cms with one BWM and one DLP/AP. Further forward, I use one trequartista (very important) and two strikers(one AF and one poacher). It's a counter-attackimg setup, scores a lot of goals (especially the trequartista role). I have a lot of extremely good players though, but it's worth trying out with lesser teams.